Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8935711 | British Journal of Anaesthesia | 2011 | 9 Pages |
Abstract
We have shown that in addition to melatonin, other structurally related indoleamine compounds have effects on NFκB activation and cytokine expression, GSH, mitochondrial membrane potential, and metabolic activity in endothelial cells cultured under conditions mimicking sepsis. Further work is needed to determine whether these compounds represent therapeutic approaches for disrupting the oxidative stress-inflammatory response signalling pathway in sepsis.
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Authors
D.A. Lowes, A.M. Almawash, N.R. Webster, V.L. Reid, H.F. Galley,