Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8936060 | British Journal of Anaesthesia | 2011 | 10 Pages |
Abstract
The results provide strong evidence that reductions in rCBF in the thalamus and precuneus are functionally related to propofol-induced unconsciousness independently of any non-specific effects of propofol. These observations confirm that the thalamus and precuneus are key elements to understand how general anaesthetics cause unconsciousness and how patients wake up from anaesthesia. Furthermore, they are consistent with the notion that anaesthetic-induced unconsciousness is associated with reduced cholinergic activation.
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Authors
G. Xie, A. Deschamps, S.B. Backman, P. Fiset, D. Chartrand, A. Dagher, G. Plourde,