Article ID Journal Published Year Pages File Type
8937349 British Journal of Anaesthesia 2009 7 Pages PDF
Abstract
The target plasma concentration for fibrinogen replacement was predicted by these in vitro results to be greater than 200 mg dl−1 as only these concentrations optimized the rate of clot formation. This concentration is twice the level suggested by the current transfusion guidelines. Although improved, clots were prone to fibrinolysis indicating that the efficacy of fibrinogen therapy may be influenced by co-existing fibrinolytic tendency occurring during dilutional coagulopathy.
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