Efficacy of intracarotid propofol infusion and impact of cerebral blood flow alterationâ€

Compared with i.v. propofol infusion, intracarotid infusion could reach and maintain the target anaesthetic depth with less dosage and without affecting MAP. In addition, increase of cerebral blood flow requires a higher propofol dose, prolongs onset, and shortens recovery time during intracarotid propofol anaesthesia, indicating that patients with a cerebral hyperperfusion state may need higher dose of anaesthetics during the Wada test.