| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8937723 | British Journal of Anaesthesia | 2008 | 5 Pages |
Abstract
Propofol metabolism in neonates differs from adults, reflecting the age-dependent limited glucuronidation capacity. Hydroxylation to quinol metabolites already contributes to propofol metabolism. These differences likely explain the PMA- and PNA-dependent reduced propofol clearance in neonates.
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Authors
K. Allegaert, J. Vancraeynest, M. Rayyan, J. de Hoon, V. Cossey, G. Naulaers, R. Verbesselt,