| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8938561 | British Journal of Anaesthesia | 2007 | 7 Pages |
Abstract
Sevoflurane improves post-ischaemic contractile recovery via activation of PKC-α. ROS production, but not opening of mitoK+ATP channels, precedes PKC-α translocation towards mitochondria. This study shows the involvement of Ca2+-dependent PKC-α in addition to the well-established role of Ca2+-independent PKC isoforms in sevoflurane-induced cardioprotection.
Keywords
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Authors
R.A. Bouwman, R.J.P. Musters, B.J. van Beek-Harmsen, J.J. de Lange, R.R. Lamberts, S.A. Loer, C. Boer,