| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8938609 | British Journal of Anaesthesia | 2007 | 9 Pages |
Abstract
These results suggest that DADLE provides limited neuroprotection to relatively ischaemia-resistant regions but not to selectively vulnerable regions. This was probably mediated by DOP stimulation. Pre-ischaemic treatment with a DOP antagonist, regardless of co-administration of DADLE, worsened neuronal damage at the selectively vulnerable regions only after mild forebrain ischaemia. These data suggest that DOP activation with endogenous DOP ligand may be involved in self-protecting ischaemia-sensitive regions of the brain.
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Authors
M. Iwata, S. Inoue, M. Kawaguchi, M. Nakamura, N. Konishi, H. Furuya,