Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8939930 | British Journal of Anaesthesia | 2006 | 11 Pages |
Abstract
All LA tested inhibited the activation of human NMDA receptors in a concentration dependent fashion. This effect may contribute to reduced hyperalgesia and opiate tolerance observed after systemic administration of LA. The effect is independent of the charge of LA; site of action is intracellular. The mechanism of action may be mediated by inhibition of PKC.
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Authors
K Hahnenkamp, M.E. Durieux, A Hahnenkamp, S.K. Schauerte, C.W. Hoenemann, V Vegh, G Theilmeier, M.W. Hollmann,