Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8942941 | Carbohydrate Polymers | 2018 | 24 Pages |
Abstract
Glutaraldehyde-crosslinked chitosan nanoparticles (Chi-NPs) were prepared reproducibly via miniemulsion crosslinking for effective adsorption of the active pharmaceutical ingredient (API) Diclofenac (DCL). Three different molecular weights (MWs) of highly deacetylated (>90%) chitosans (low, medium and high MW) were used to vary the disperse phase viscosity. Particle formation was evaluated ranging from one to seven homogenization cycles at 40â¯MPa. Particles were prepared successfully with the low and medium MW chitosan in the range of 125â¯nm-250â¯nm (z-average). In HPLC assisted, static adsorption experiments, all particles showed a rapid sorption rate (<2â¯min) with an adsorption capacity of up to 256.2â¯mgâ¯gâ1 DCL. Modelling of adsorption isotherms resulted in a qmax 358.3â¯mgâ¯g-1 for Langmuir and 502.5â¯mgâ¯gâ1 for Sips, respectively. Membrane adsorbers were prepared by processing Chi-NPs into porous polyether sulfone microfiltration membranes via a casting and phase inversion process, resulting in an adsorption capacity of up to 3.6â¯mgâ¯m-2 DCL in dynamic adsorption experiments.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Benjamin R. Riegger, Regina Kowalski, Luise Hilfert, Günter E.M. Tovar, Monika Bach,