| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8945837 | Journal of Traditional Chinese Medicine | 2018 | 8 Pages |
Abstract
Our data suggest that the leptin-mediated JAK/STAT signaling pathway is involved in the process of renal interstitial fibrosis in UUO rats. QSG inhibited the activity of the signaling pathway, reduced the activity of NF-kB and inflammatory effect, and the transdifferentiation in the renal tubular epithelial cells. Treatment with QSG may delay the renal fibrosis and protect the renal function from damage following UUO in rats.
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Authors
Wang Yiping, Wang Dong, Jin Hua, Yu Min, Zhang Lei,