| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8949928 | Pathology - Research and Practice | 2018 | 6 Pages |
Abstract
IDO positive, B7-H1 positive, and combined IDO/B7-H1 positive tumors exhibited significant correlations with lymphocytic infiltration, perineural invasion, TNM status, and pathologic grade (pâ¯<â¯.05), which tended to show strong correlations with malignant progression of PC. Also, IDO correlated with diabetes mellitus (DM) and HAD scale and B7-H1 correlated with smoke (pâ¯<â¯.05). In addition, the correlation analysis indicated that IDO had a positive correlation with B7-H1 (pâ¯<â¯.05). Moreover, the results showed that a combination of IDO and B7-H1 expressions could serve as independent prognostic marker after adjusting by Cox proportional hazards regression models (pâ¯<â¯.05). IDO and B7-H1 expressions were observed in patient with PC tissues and are important markers for PC malignant progression. A combination of IDO and B7-H1 expression can be served as an independent prognostic marker for PC.
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Authors
Liancai Wang, Qingyong Ma, Deyu Li, Senmao Mu, Yong Li, Yafeng Wang, Pengfei Shi, Haibo Yu, Chunhui Gao, Kun Guo, Zhuoli Zhang,