| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8951032 | Respiratory Physiology & Neurobiology | 2018 | 36 Pages |
Abstract
When exposed to intermittent hypoxia, animals showed a significant alteration in energy metabolism towards anaerobic pathways and signs of OS imbalance. A compensatory response was observed over time. Our data also indicates an excess production of vitamin B3, liver function modulations and a stimulation of creatine synthesis which could be used to evaluate the ChIH repercussions. As well, TMAO and allantoin could constitute interesting biomarker candidates, respectively in the context of cardiovascular risk and OS associated to OSA.
Keywords
FMO3HIF1CPAPGLUTTCANrf2HRETMAFiO2PDK1PLS-DANAFLDTMAO1H NMRAUCROSHydrogen peroxidefree induction decaysObstructive sleep apnoeatricarboxylic acidOsaNonalcoholic fatty liver diseasePartial least squares discriminant analysistrimethylamineOxidative stressGlucose transporterFIDUpper airwaySODSuperoxide dismutaseNF-E2 related factor 2hypoxia inducible factor 1Hypoxia responsive elementContinuous positive airway pressureMetabonomicarea under the curveH2O2intermittent hypoxiachronic intermittent hypoxiaproton nuclear magnetic resonancePyruvate dehydrogenase kinase 1Fraction of inspired oxygenGAMTGuanidinoacetate methyltransferaseReactive oxygen species
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Authors
Stéphanie Conotte, Alexandra Tassin, Raphaël Conotte, Jean-Marie Colet, Karim Zouaoui Boudjeltia, Alexandre Legrand,