Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8951210 | Journal of Indian College of Cardiology | 2018 | 5 Pages |
Abstract
These findings suggest that possible role ofHSP90α polymorphism in the etiology of ARVC/D. The 'G' allele of HSP90α polymorphism damages the 3-D native conformations, which is required for the interaction between client proteins such as desmosomes, ryanodine receptor-2 and sodium channel leading to mislocalization of these proteins. Furthermore, loss of inhibitory interaction between HSP90α protein and Apaf-1 trigger apoptosis.
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Authors
C. Sandeep Kumar, Altaf Ali, Sairam Manchineela, Ananthapur Venkateshwari, Calambur Narasimhan, Pratibha Nallari,