Article ID Journal Published Year Pages File Type
8951210 Journal of Indian College of Cardiology 2018 5 Pages PDF
Abstract
These findings suggest that possible role ofHSP90α polymorphism in the etiology of ARVC/D. The 'G' allele of HSP90α polymorphism damages the 3-D native conformations, which is required for the interaction between client proteins such as desmosomes, ryanodine receptor-2 and sodium channel leading to mislocalization of these proteins. Furthermore, loss of inhibitory interaction between HSP90α protein and Apaf-1 trigger apoptosis.
Related Topics
Health Sciences Medicine and Dentistry Cardiology and Cardiovascular Medicine
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