Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8951252 | Journal of Vascular Surgery | 2018 | 9 Pages |
Abstract
An in vivo animal model of critical limb ischemia, consisting of surgical excision of the superficial femoral artery, presents limitations to prove the efficacy of therapies designed to improve arterial perfusion and collateral growth, such as stem cell treatment. The natural propensity of collaterals to overcome the proximal arterial occlusion usually precludes the onset of significant critical limb ischemia. We evaluated the efficacy of a new model of rabbit hindlimb ischemia created through a percutaneous approach using embolization of distal hind vessels by calibrated particles that may overcome some of limitations of existing animal models and prove useful for future studies.
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Authors
Costantino MD, Gabriel MD, Guillaume MD, Valerie MD, Emmanuel MD, PhD, Olivier MD, PhD, Patrick MD, PhD, Philippe MD, PhD, Marc MD, PhD,