Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8952955 | Surgery | 2018 | 9 Pages |
Abstract
Ex vivo gene correction of autologous hepatocytes in fumarylacetoacetate hydrolase-deficient pigs can be performed using hepatocyte spheroids or single-cell hepatocytes, with spheroids showing a more heterogeneous distribution within the liver and higher risks for portal vein thrombosis and increased portal pressures.
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Authors
Clara T. MD, Raymond D. PhD, Kari L. Allen, Zeji PhD, Rebekah M. Guthman, Robert A. PhD, Bruce Amiot, Aditya PhD, Mukesh K. PhD, Lukkana PhD, Timothy R PhD, Scott L. MD, PhD, Joseph B. MD, PhD,