Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8956145 | EBioMedicine | 2018 | 13 Pages |
Abstract
Berberine reduced acetyl CoA contents by limiting fatty acid oxidation and increased MPC1 degradation via preserving acetylation, thereby restraining HGP by blocking mitochondrial import of pyruvate. These findings suggest that limitation of mitochondrial pyruvate import might be a therapeutic strategy to prevent excessive hepatic glucose production.
Keywords
DCAG-6-Paseperoxisome proliferator-activated receptor-γ coactivator-1αKCTPDKTMZPDHSirt3THPHGPPEPCKPGC-1αHFDAMPKMPCTACAMP-activated protein kinaseNEFAsBerberinetriglycerideHepatic glucose productionMitochondrial pyruvate carrierDichloroacetatehigh-fat dietphosphoenolpyruvate carboxykinaselactate dehydrogenaseLDHNAMNicotinamidepyruvate dehydrogenasePyruvate dehydrogenase kinasetricarboxylic acid cycletotal cholesterolglucose-6-phosphataseGluconeogenesis
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Authors
Aiyun Li, Qun Liu, Qiang Li, Baolin Liu, Yang Yang, Ning Zhang,