| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8956269 | Cytotherapy | 2018 | 11 Pages |
Abstract
These data show that DNA methylation of MSCs is only marginally affected by priming, whereas culture expansion and subsequent increased cellular interactions have a large impact on methylation. On account of this study, we suggest that DNA methylation analysis is a useful quality control tool for culture expanded therapeutic MSCs.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cell Biology
Authors
Samantha F.H. De Witte, Fleur S. Peters, Ana Merino, Sander S. Korevaar, Joyce B.J. Van Meurs, Lisa O'Flynn, Steve J. Elliman, Philip N. Newsome, Karin Boer, Carla C. Baan, Martin J. Hoogduijn,