Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8958051 | American Journal of Obstetrics and Gynecology | 2018 | 16 Pages |
Abstract
In preterm lambs that were exposed to antenatal corticosteroids, high maternofetal plasma betamethasone concentrations did not correlate with improved lung maturation. The largest and most consistent improvements in lung maturation were in animals that were exposed to either the clinical course of Celestone Chronodose or a low-dose betamethasone phosphate infusion to achieve a fetal plasma betamethasone concentration of approximately 2 ng/mL for 26 hours. The duration of low-concentration maternofetal steroid exposure, not total dose or peak drug exposure, is a key determinant for antenatal corticosteroids efficacy. These findings underscore the need to develop an optimized steroid dosing regimen that may improve both the efficacy and safety of antenatal corticosteroids therapy.
Related Topics
Health Sciences
Medicine and Dentistry
Medicine and Dentistry (General)
Authors
Matthew W. PhD, Masatoshi MD, Haruo MD, Shimpei MD, Shinichi MD, Takushi MD, Yusaku MD, Timothy J. PhD, Michael PhD, Peter J. PhD, Gabrielle C. PhD, Augusto MD, Demelza PhD, Lucy BSc, Matthew S. PhD, John P. MD, Alan H. MD, PhD,