| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8959050 | Biological Psychiatry | 2018 | 9 Pages |
Abstract
The dose-related GlyT1 occupancy of PF-03463275 is linear. While PF-03463275 did not show evidence of facilitating N-methyl-D-aspartate receptor function in the ketamine assay, it enhanced neuroplasticity in SZs. These findings provide support for a clinical trial to test the ability of PF-03463275 to enhance cognitive remediation toward addressing cognitive impairments associated with schizophrenia.
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Authors
Deepak Cyril D'Souza, Richard E. Carson, Naomi Driesen, Jason Johannesen, Mohini Ranganathan, John H. Krystal,