Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8959224 | Progress in Neurobiology | 2018 | 175 Pages |
Abstract
Here, I will first provide a comprehensive picture of the histology, physiology, and neurochemistry of the normal SGR. Then, I will analytically discuss the SGR circuits that have been directly demonstrated or deductively envisaged in the course of the intensive research on this area of the spinal cord, with particular emphasis on the pathways connecting the primary afferent fibers and the intrinsic neurons. The perspective existence of neurochemically-defined sets of primary afferent neurons giving rise to these circuits will be also discussed, with the proposition that a cross-talk between different subsets of peptidergic fibers may be the structural and functional substrate of additional gating mechanisms in SGR. Finally, I highlight the role played by slow acting high molecular weight modulators in these gating mechanisms.
Keywords
5-HTTRPA1TRPV1TrpAMPICCGFPeGFPSDHFRAPHRPNT3ERKGADNOSNPYSGRDOPLTMnAChRAMPAAMPARCCKNGFCGRPGad67GLASTNMDAGDNFGLT-1N-methyl-d-aspartateMOPnNOSRIAISHTrkBPKCγPKCNMDARGLYT2RVMGRPGRPRVGATVGlut3vesicular glutamate transporter 3VGLUT1mGluRVGLUT2TRPM8GAD65NK1mEPSCWDRsEPSCtrkACLRRAMP1receptor activity-modifying protein 1SSTRLDCVEnkephalinsNeuromodulatorsSSVHTMNK2GFRα1NOPGDNF family receptor α1TrkCNKASRIFSTTmIPSCGalR1GalR2tropomyosin receptor kinase AGALR3LGVLarge granular vesicleNK3NT4lamina IINKBGastrin releasing peptide receptorrostroventral medullaFRPSGalanin receptor 2PPAFGDNF Family LigandsBDNFglutamic acid decarboxylaseIn situ hybridizationNMDA receptorRMNsIPSC[Ca2+]iγ-amino-butyric acidμ Opioid receptoradenosine monophosphateAnatomyAChAcetylcholineα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acidPrimary afferent fibersNeurotransmittersEnkimmunoreactiveImmunocytochemistryTemHistologytropomyosin receptor kinase Blong term potentiationLTPKOPH-currentspontaneous excitatory postsynaptic currentminiature inhibitory postsynaptic currentSpontaneous inhibitory postsynaptic currentminiature excitatory postsynaptic currentvesicular GABA transporterRETvesicular glutamate transporter 2vesicular glutamate transporter 1PainSpinothalamic tractdynorphinradioimmunoassaySerotoninneuronal nitric oxide synthaseSomatostatinSensory systemdorsal hornSpinal cordwide dynamic rangenociceptionintracellular Ca2+ concentrationnerve growth factorglial-derived neurotrophic factorBrain-derived neurotrophic factorPrimary afferent fiberPhysiologylucifer yellowSubstance Psubstantia gelatinosaDynfluoride-resistant acid phosphatasemAChTransmission electron microscopyNeurochemistryneurokinin ANeurokinin Bneurotrophin-3Neurotrophin-4Nitric oxidenitric oxide synthasePAFraphe magnus nucleusMolecular weighttransient receptor potentialPADHorseradish peroxidaseenhanced green fluorescent proteinProtein kinase Ccalcitonin gene-related peptidecholecystokininextracellular signal-regulated kinaseGABAGABAARGABABRGastrin releasing peptidedorsal root ganglialarge dense core vesicleglutamate transporter-1glycine transporter 2AMPA receptorGABAA receptorGABAB receptornicotinic acetylcholine receptorSomatostatin receptorGalanin receptor 1Metabotropic glutamate receptorcalcitonin receptor-like receptorNeuropeptide Y
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Authors
Adalberto Merighi,