Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8959266 | Saudi Journal of Biological Sciences | 2018 | 7 Pages |
Abstract
Mikania cordata is widely used for the treatment of cuts, wounds, and dengue fever in Bangladesh. In the present study, essential oil (12.5, 25 and 50â¯mg/kg) and two extracts, viz., chloroform and ethyl acetate extracts (200, 400, 800â¯mg/kg b.w.) were tested for peripheral and central anti-nociceptive activity by acetic acid-induced writhing and hot plate method, respectively. Carrageenan-induced rat paw edema assay and yeast-induced hyperthermia assay were also carried out to evaluate anti-inflammatory and antipyretic properties of oil and extracts, respectively at aforesaid doses. The essential oil (50â¯mg/kg), chloroform extract (800â¯mg/kg) and ethyl acetate extract (800â¯mg/kg) showed potent peripheral anti-nociceptive activity having 47.33%, 29.33% and 16.65% of writhing inhibition, respectively, comparable with standard diclofenac (52.0%). Essential oil (50â¯mg/kg), chloroform extract (800â¯mg/kg) and ethyl acetate extract (800â¯mg/kg) presented promising central anti-nociceptive activity as well having 95.86%, 79.18% and 42.37% elongation of reaction time, respectively, at 90â¯min after administration of essential oil, ethyl acetate extract and 60â¯min after administration of chloroform extract. In anti-inflammatory activity screening, the essential oil (50â¯mg/kg) produced the highest 72.80% edema inhibition at 4â¯h after administration of carrageenan which was comparable with that of standard phenylbutazoe (87.87%). On the other hand, chloroform extract (800â¯mg/kg) and ethyl acetate extract (800â¯mg/kg) showed up to 34.31% and 15.27% of edema inhibition, respectively, at 4â¯h after administration of carrageenan. In antipyretic assay, the essential oil and chloroform extract displayed a strong antipyretic effect in yeast-induced rats, whereas the ethyl acetate extract had no antipyretic activity. The present study revealed anti-nociceptive, anti-inflammatory and antipyretic potential of M. cordata which could be the therapeutic option against fever, inflammations as well as painful conditions and confirmed the traditional use of M. cordata.
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Authors
Shah Alam Siddiqui, Atiqur Rahman, M. Oliur Rahman, Mohammad Ahsanul Akbar, A.S. Shamsur Rouf, Mohammad Ajmal Ali, Fahad M.A. Al-Hemaid, Mohammad Abul Farah,