| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8960763 | Brain, Behavior, and Immunity | 2018 | 12 Pages |
Abstract
Thus, hypothalamic HIF-1 is increased during DIO, and its inhibition worsens the obesity-associated metabolic phenotype. Thus, hypothalamic HIF-1 emerges as a target for therapeutic intervention against obesity.
Keywords
POMCpro-opiomelanocortinARNTDIOT2DsFaspVHLRERBATAgRPNPYPGC-1alphaGTTHIF-1ACTHGFAPvon Hippel–Lindau tumor suppressorHDFperoxisome proliferator-activated receptor gamma coactivator 1-alphaaryl hydrocarbon receptor nuclear translocatorsaturated fatty acidsHypothalamic inflammationWhite adipose tissueMetabolic diseasesglucose tolerance testType 2 diabetesHigh fat dietFIHArcObesityRespiratory exchange ratioarcuate nucleusadrenocorticotropic hormoneHypothalamusGlial fibrillary acidic proteinagouti-related peptidediet-induced obesityWATNeuropeptide Y
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Authors
Joana M. Gaspar, Natália Ferreira Mendes, Felipe Corrêa-da-Silva, José C. de Lima-Junior, Rodrigo C. Gaspar, Eduardo R. Ropelle, Eliana P. Araujo, Humberto M. Carvalho, LÃcio A. Velloso,