| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8961231 | Ultrasonics Sonochemistry | 2018 | 6 Pages |
Abstract
In this work, a novel, biocompatible, non-immunogenic and reductive-responsive magnetic starch-based microcapsules (RMSMCs) were designed and fabricated successfully via a facile sonochemical method for targeted delivery and triggered release of hydrophobic drugs. TEM image indicated that oleic acid (OA) modified Fe3O4 nanoparticles (OA-Fe3O4 NPs) were encapsulated into RMSMCs. The obtained RMSMCs were endowed with magnetism for drug targeted delivery because that the superparamagnetic OA-Fe3O4 NPs were encapsulated into RMSMCs. Moreover, Coumarin 6 (C6), a green fluorescent dye, was used as a model hydrophobic drug and loaded into RMSMCs. As drug carriers, the obtained spherical RMSMCs with the average size of 2â¯Î¼m presented excellent reductive-responsive release ability for hydrophobic drugs. Accordingly, the obtained RMSMCs would be promising carriers for targeted delivery and triggered release of hydrophobic drugs in biomedical applications.
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Authors
Lifeng Xu, Shuangling Zhong, Chao Shi, Yuexin Sun, Shengnan Zhao, Yan Gao, Xuejun Cui,