Mitochondrial disorders of the retinal ganglion cells and the optic nerve

Article ID	Journal	Published Year	Pages	File Type
8962078	Mitochondrion	2018	29 Pages	PDF

Abstract

MON needs to be appreciated, requires extensive diagnostic work-up, and supportive treatment should be applied although loss of vision, as the most severe outcome, can often not be prevented.

Keywords

LHON OPN VEP PCH CMT MID WES RCC Charcot-Marie-Tooth disease IPSCs MELAS RGC MDS KSS RNFL EMEA ERG NBIA CPEO CoQ MERRF NARP ADOA aroA Mitochondrial depletion syndrome AION ROS autosomal dominant optic atrophy adenosin triphosphate ATP mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes European Medicine Agency Mitochondrial disorder electroretinogram MRI Oct neurodegeneration with brain iron accumulation Tem Magnetic resonance imaging Whole exome sequencing Optical coherence tomography CNS mtDNA Respiratory chain SANDO Induced pluripotent stem cells Retinal ganglion cells Kearns-Sayre Syndrome Leigh syndrome Wolfram syndrome central nervous system Optic nerve Oxidative phosphorylation Retinal nerve fiber layer cerebro-spinal fluid CSF Respiratory chain complex MON Mitochondrial Transmission electron microscopy Leber hereditary optic neuropathy Anterior ischemic optic neuropathy optic neuropathy Posterior Ischemic Optic Neuropathy olivary pretectal nucleus Pion Chronic progressive external ophthalmoplegia Reactive oxygen species

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biophysics

Mitochondrial disorders of the retinal ganglion cells and the optic nerve

Authors

Josef Finsterer, Michelangelo Mancuso, Davide Pareyson, Jean-Marc Burgunder, Thomas Klopstock,