Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8962086 | Mitochondrion | 2018 | 29 Pages |
Abstract
Exceed lipid synthesis, induction of the excitotoxicity in neurodegenerative disorders could be controlled by SDH through direct and indirect mechanism. In addition, mutation in SDH correlates with the onset of neurodegenerative disorders. Therefore, SDH could behave as a key regulator in neuroprotection. This review will present recent findings which are about SDH activity and related pathways which could play important roles in neuronal survival. Additionally, we will discuss about all possibilities which candidate SDH as a neuroprotective agent.
Keywords
SOD1AβmTORNOSAMPAMPTPN-methyl-d-aspartatePINK1HIF-1αα-amino-3-hydroxy-5-methylisoxazole-4-propionateNMDAVDACSOD2LDSSREBPmHTTMPP +mutant huntingtin proteinubiquinone oxidoreductaseTCAJnkGSHSDH1-methyl-4-phenyl-1,2,3,6-tetrahydropyridinec-Jun N-terminal kinaseMitochondrial DNAO2·−PTEN-induced putative kinase 1ROSΔψHydrogen peroxideNeurodegenerative disorderstricarboxylic acidONOOexcitotoxicityamyloid betaAlzheimer's diseaseHuntington's diseaseParkinson's diseasemtDNAHydroxyl radicalblood brain barrierBBBLipid synthesissuccinate dehydrogenasehypoxia inducible factor 1αLipid dropletsNeuroprotectionMitochondrial permeability transition poresMitochondriaNitric oxideNitric oxide synthetasemammalian target of rapamycinH2O2Mitochondrial membrane potentialsterol regulatory element binding proteinPeroxynitriteVoltage-Dependent Anion ChannelsGlutathioneReactive oxygen species
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Authors
Mohammad Jodeiri Farshbaf, Abbas Kiani-Esfahani,