Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8962258 | Molecular and Cellular Neuroscience | 2018 | 83 Pages |
Abstract
The metabotropic glutamate receptors (mGlu receptors) are G protein-coupled receptors that bind to the excitatory neurotransmitter glutamate and are important in the modulation of neuronal excitability, synaptic transmission, and plasticity in the central nervous system. Trafficking of mGlu receptors in and out of the synaptic plasma membrane is a fundamental mechanism modulating excitatory synaptic function through regulation of receptor abundance, desensitization, and signaling profiles. In this review, we cover the regulatory mechanisms determining surface expression and endocytosis of mGlu receptors, with particular focus on post-translational modifications and receptor-protein interactions. The literature we review broadens our insight into the precise events defining the expression of functional mGlu receptors at synapses, and will likely contribute to the successful development of novel therapeutic targets for a variety of developmental, neurological, and psychiatric disorders.
Keywords
ATDPSDNACECDPTZCTDCIEPP2ASCGCaMKIIpKaIP3GPCRcdk5PLCOptineurinSNAREHFSPKCGPiPTXRGSCbln1NLSDRMEVH1httGRKPICK1OPTNACTN4TRPCARF6ADP-ribosylation factor 6GPCR kinaseclathrin-independent endocytosisPP2CVFDCRIP1aPLD2CainRalGDSSAPAPα-Actinin-4Ca2+/calmodulin-dependent protein kinase IIERK1/2superior cervical ganglionGTPase Activating ProteinJNK/SAPKMAPKadenylate cyclaseCMEEndocytosispost-translational modificationlong-term depressionClathrin-mediated endocytosisSERhigh-frequency stimulationpostsynaptic densityProtein-protein interactionlong-term potentiationLTPIntracellular loopamino terminal domaincarboxy terminal domainextracellular domaintransmembrane domainCNSdiacyl glycerolDAGRegulator of G protein signalingCAMpertussis toxincentral nervous systemcyclin-dependent kinase 5nuclear localization signalGAPsmooth endoplasmic reticulumdominant negativePhosphorylationphospholipase CPhospholipase D2TraffickingLTDknockoutHuntingtinNucleus accumbensPleckstrin HomologyVesltransient receptor potential canonicalglutamate receptor interacting proteinprotein phosphatase 2Aprotein phosphatase 2Cprotein kinase AProtein kinase Cmitogen-activated protein kinasePentylenetetrazoleCalmodulinCoiled-coilExtracellular signal-regulated kinases 1/2GRIPglycosylphosphatidylinositolmGlu receptorMetabotropic glutamate receptorssoluble N-ethylmaleimide-sensitive factor attachment protein receptorMetabotropic glutamate receptorG protein-coupled receptor
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Authors
Young Ho Suh, Kai Chang, Katherine W. Roche,