EphBs and ephrin-Bs: Trans-synaptic organizers of synapse development and function

Article ID	Journal	Published Year	Pages	File Type
8962266	Molecular and Cellular Neuroscience	2018	50 Pages	PDF

Abstract

Synapses are specialized cell-cell junctions that underlie the function of neural circuits by mediating communication between neurons. Both the formation and function of synapses require tight coordination of signaling between pre- and post-synaptic neurons. Trans-synaptic organizing molecules are important mediators of such signaling. Here we discuss how the EphB and ephrin-B families of trans-synaptic organizing proteins direct synapse formation during early development and regulate synaptic function and plasticity at mature synapses. Finally, we highlight recent evidence linking the synaptic organizing role of EphBs and ephrin-Bs to diseases of maladaptive synaptic function and plasticity.

Keywords

CREB PI3K TNFα Jnk DRG GTP KCl PSD BLA eGFP shRNA Aβ FRAP SAM FAK ERK RGC SRC CRD APP AMPAR ABL CaMKII pKa Synaptogenesis IL-1β TTX PSD-95 c-fos Rac1 CCI PS1 PKC NMDAR GPi mEPSC PDZ PAK βgal Presenilin-1 TLR4 GIT1 TCI CDC42 GEF SH2 FNIII MuSK GRB SAP102 Maladaptive plasticity PSD-93 ePHS dorsal root ganglion basolateral amygdala membrane-associated guanylate kinase MAPK MAPK/ERK kinase short-hairpin RNA Tiam1 TKO α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor chronic constriction injury amyloid-β MAGUK Ephrins Eph long-term depression Pick ephrin interleukin 1β β-galactosidase Alzheimer's disease tetrodotoxin Post-synaptic density long-term potentiation LTP GDP tumor necrosis factor α miniature excitatory post-synaptic current cysteine-rich domain Neuropathic pain DIV Sarcoma cell division cycle 42 human embryonic kidney cells 293 retinal ganglion cell dorsal horn guanine nucleotide exchange factor phosphoinositide-3 kinase fluorescence recovery after photobleaching fibronectin type III Cerebrospinal fluid CSF MEK LTD Src Homology 2 cyclic AMP response element binding protein enhanced green fluorescent protein amyloid precursor protein post-synaptic density protein 95 protein kinase A Protein kinase C mitogen-activated protein kinase Synaptic plasticity Jun kinase Potassium chloride calcium/calmodulin-dependent kinase II extracellular signal-regulated kinase Muscle-specific kinase p21-activated kinase focal adhesion kinase GRIP glycosylphosphatidylinositol Guanosine triphosphate guanosine diphosphate N-methyl-d-aspartate receptor Toll-like receptor 4