Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8962468 | Reproductive Toxicology | 2018 | 16 Pages |
Abstract
In recent years several OECD test guidelines have been updated and some will be updated shortly with the requirement to measure thyroid hormone levels in the blood of mammalian laboratory species. There is, however, an imperative need for clarification and guidance regarding the collection, assessment, and interpretation of thyroid hormone data for regulatory toxicology and risk assessment. Clarification and guidance is needed for 1) timing and methods of blood collection, 2) standardization and validation of the analytical methods, 3) triggers for additional measurements, 4) the need for T4 measurements in postnatal day (PND) 4 pups, and 5) the interpretation of changes in thyroid hormone levels regarding adversity. Discussions on these topics have already been initiated, and involve expert scientists from a number of international multisector organizations. This paper provides an overview of existing issues, current activities and recommendations for moving forward.
Keywords
TSHJRCExtended One-Generation Reproductive Toxicity StudyEDSPEOGRTSECHARIAEPAOECDDArTEFSACROPNDETsHPLC–MSAdversityenzyme linked immunosorbent assayEnvironmental Protection AgencyEuropean Chemicals AgencyEndocrine disruptionEuropean Food Safety AuthorityEndocrine Disruptor Screening ProgramTriiodothyronineELISAthyroxineANSEStest guidelinegestation daypostnatal dayContract research organizationNGOnon-governmental organizationOrganisation for Economic Co-operation and DevelopmentCoefficient of VariationHigh performance liquid chromatography–mass spectrometryThyroid hormonesEuropean Commission
Related Topics
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Environmental Science
Health, Toxicology and Mutagenesis
Authors
Manon Beekhuijzen, Steffen Schneider, Narinder Barraclough, Nina Hallmark, Alan Hoberman, Sheri Lordi, Mary Moxon, Deborah Perks, Aldert H. Piersma, Susan L. Makris,