| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8963686 | Journal of Allergy and Clinical Immunology | 2018 | 19 Pages |
Abstract
Genetic deletion of the IL-33 receptor paradoxically increases TSLP production, which stimulates the emergence of IL-9+ and IL-13+ ILC2s and mast cells and leads to development of chronic experimental asthma. An anti-TSLP antibody abrogates all pathologic features of asthma in this model.
Keywords
FOXP3Natural regulatory TMast cell protease 1TSLPRThymic stromal lymphopoietin receptorIL-33 receptorKLRG1IL-9ICOSnTregTSLPILC2ST2MCP1FITCAPCBALTregILCAsthmaallophycocyaninforkhead box P3innate lymphoid celltype 2 innate lymphoid cellsphycoerythrinfluorescein isothiocyanatebronchoalveolar lavageThymic stromal lymphopoietinMast cellsRegulatory T knockouttype 2 innate lymphoid cellwild-typeInducible costimulator
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Authors
Mukesh PhD, Sucai PhD, Lidia PhD, Anand PhD, Magdalena M. MD, PhD, Rafeul MD, PhD,