| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8963701 | Journal of Allergy and Clinical Immunology | 2018 | 11 Pages |
Abstract
We identified 5 DA-associated potential regulatory SNPs. Four variants exhibited effects on gene regulation (ATF rs11571537, CDH17 rs2446824 and rs2513789, and TACR1 rs2287231). AÂ fifth variant (FAM71A rs147978008) showed nonrisk allele preferential binding to H1 histones. These results demonstrate that many DA-associated genetic variants likely act by modulating gene regulation.
Keywords
EMSACDH17SiCZBTB16Nano-LC-MS/MSNGSCEBPBChIP-SeqMAFATF3Luciferase assayElectrophoretic mobility shift assayAsthmaOccupational asthmaOligonucleotideIsocyanateBioinformaticsNext-generation sequencingGene regulationchromatin immunoprecipitation sequencingDapaDiisocyanateminor allele frequencyactivating transcription factor 3Genome-wide association studyGWASHistoneSingle nucleotide polymorphismSpecific inhalation challengeSNPGeneticFunctional genomics
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Authors
David I. MD, FAAAAI, Zana L. PhD, Banu MS, Jianbo PhD, Leah PhD, Daniel BS, André MD, FAAAAI, Maria-Jesús MD, Catherine MD, Xavier MD, Santiago MD, PhD, Susan MD, FAAAAI, Joaquin MD, PhD, FAAAAI, Louis Philippe MD, Matthew T. PhD, Kenneth PhD,