Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8964649 | Ophthalmology Retina | 2018 | 14 Pages |
Abstract
Most candidate gene studies of ROP have limitations such as inability to replicate results, conflicting results from various studies, small sample size, and differences in clinical characterization. Additional difficulty arises in separating the contribution of genetic factors such as Wnt signaling to ROP and prematurity. Although studies have implicated involvement of multiple signaling pathways in ROP, the genetics of ROP have not been clearly elucidated. Next-generation sequencing and genome-wide association studies have potential to expand future understanding of underlying genetic risk factors and pathophysiology of ROP.
Keywords
TNFROPHIFPDGFIGF-1OIReNOSAMDRASEPOLRPFEVRBDNFADAMangiopoietinerythropoietininsulin-like growth factor-1Anginterleukina disintegrin and metalloproteinasediabetic retinopathyOxygen-induced retinopathyRetinopathy of prematurityage-related macular degenerationgestational ageendothelial nitric oxide synthaserenin-angiotensin systemHypoxia-inducible factorVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)platelet-derived growth factortumor necrosis factorAGTBirth weightFamilial exudative vitreoretinopathySingle-nucleotide polymorphismSNPAngiotensinogen Gene
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Authors
Ryan BS, Sang Jin MD, PhD, J. Peter MD, MPH, R.V. Paul MD, Kemal PhD, Kent D. PhD, Xiaohui MD, Yii-Der Ida PhD, Jerome I. MD, Charles MD, Michael F. MD,