Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8969765 | Vaccine | 2005 | 9 Pages |
Abstract
Plants have become, over the last ten years, a suitable alternative to microbial and animal cell factories for the production of clinically-useful, therapeutic proteins. Besides the well known advantage of low-cost and large-scale production of safe and biologically active mammalian proteins, plants also are able to perform most post-translational maturations required for biological activity and suitable pharmacokinetics of recombinant therapeutic proteins. In this short review we focus on glycosylation and proteolytic processing of plant-made pharmaceuticals during their transport through the plant cell's secretory pathway. We also address the practical implications of these important processes on the effectiveness of plant molecular pharming systems.
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Loïc Faye, Aurelia Boulaflous, Meriem Benchabane, Véronique Gomord, Dominique Michaud,