Sex differences in effects of cigarette smoking and 24-hr abstinence on plasma arginine vasopressin

The present study examined plasma arginine vasopressin (AVP) levels in 18 smokers (10 men, 8 women) and in 22 non-smokers (12 men, 10 women). Non-smokers came to the laboratory once, whereas smokers came twice: while smoking freely and following 24-hr abstinence. Plasma was collected for AVP assessment; salivary cotinine and expired carbon monoxide levels confirmed smoking status. Among non-smokers, men had higher AVP levels than did women (p < 0.05). Among smokers, however, women displayed higher AVP levels than did men both while smoking and following abstinence (p's < 0.05). Among men, smoking resulted in lower AVP levels compared to non-smoking men. In contrast, women who smoked displayed higher AVP levels compared to their non-smoking counterparts. AVP levels were not affected by 24-hr abstinence among smokers, regardless of sex, which suggests that dysregulation in AVP levels in tobacco smokers continues even following 24-hr abstinence. Findings are consistent with previous reports of elevated Th1/Th2 immune function among female smokers compared to male smokers and to male and female non-smokers. Data suggest sex-dependent AVP changes during smoking that could contribute to negative impact of smoking on cardiovascular health.

► Cardiovascular effects of nicotine may be explained through release of arginine vasopressin (AVP). ► AVP levels of male and female non-smokers and smokers while smoking and following 24-hr abstinence measured. ► Women smokers displayed higher AVP levels than did male smokers while smoking and following abstinences. ► Among men, smoking resulted in lower AVP levels compared to non-smoking men. ► Women who smoked displayed higher AVP levels compared to their non-smoking counterparts.