Effects of opioid antagonists and morphine in a hippocampal hypoxia/hypoglycemia model

Conversely, when onset of hypoxia/hypoglycemia was delayed for 3 h after morphine termination, a significantly improved recovery was observed. Similarly, in vivo administration of morphine 12 h prior to slice preparation resulted in a dose dependent improved recovery of field potentials after hypoxia/hypoglycemia. These results provide evidence that preconditioning with morphine is able to induce neuroprotective effects.