| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8998252 | Neuropharmacology | 2005 | 13 Pages |
Abstract
These results show that tamoxifen can afford protection against brain mitochondrial injury promoted by several oxidative stress-related events such as hydrogen peroxide production, lipid peroxidation and the induction of the MPT. Since numerous neurodegenerative diseases are intimately related with mitochondrial dysfunction, future therapeutical strategies could be designed taking into account this protective role of tamoxifen.
Keywords
RCRΔΨmOHTAMMPTGSSGNADPHGSHMPP+NAD+NADP+TPP+mitochondrial permeability transition poreCSATAMtamoxifenOxidative stresscyclosporin ANeuroprotectionBrainMitochondriaNADHrespiratory control rationicotinamide adenine dinucleotidenicotinamide adenine dinucleotide phosphatehydroxytamoxifenMitochondrial transmembrane potentialreduced glutathioneoxidized glutathionetetraphenylphosphonium ion
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Authors
Paula I. Moreira, José B. Custódio, Catarina R. Oliveira, Maria S. Santos,