Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8998332 | Neuropharmacology | 2005 | 10 Pages |
Abstract
Repeated bath or focal applications of 3,5-DHPG induced a progressive decline in the amplitude of the membrane depolarization, suggesting that group I mGluRs undergo receptor desensitization. Interestingly, in the presence of the mGluR5 blocker, SIB 1757, this event was not observed, whereas it occurred in LY 367385. PKC blockers chelerythrine and calphostin C mimicked the inhibitory effect of SIB 1757. In a subset of interneurons, in MPEP or SIB 1757, 3,5-DHPG induced a 0.5-1Â Hz oscillatory response, that was prevented by L-type Ca2+ channel blockers, and by the tyrosine kinase inhibitors genistein and lavendustin. Together, these data suggest that mGluR5 modulates mGluR1 activity to shape cell excitability.
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Authors
P. Bonsi, D. Cuomo, C. De Persis, D. Centonze, G. Bernardi, P. Calabresi, A. Pisani,