| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8999858 | Phytomedicine | 2005 | 5 Pages |
Abstract
The effect of the extracts of Epimedium brevicornum Maxim. was investigated on proliferative activity in vitro. The osteoblast-like UMR106 cells was employed as an osteoblast model. The EtOH extract and the n-butanol fraction from the crude extract were found to show proliferation stimulating activity. Three flavonoid compounds (icariin, epimedin B and epimedin C) were isolated from this fraction by activity-guided assay, and the effects on cell proliferation were studied. Icariin produced the most significant promoting effect on the proliferation in osteoblast-like UMR106 cells. The results suggested that E. brevicornum Maxim. extracts might have potential activity against osteoporosis, and flavonoids such as icariin might be the active constituents stimulating osteoblasts.
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Authors
F.-H. Meng, Y.-B. Li, Z.-L. Xiong, Z.-M. Jiang, F.-M. Li,