Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9004417 | Biomedicine & Pharmacotherapy | 2005 | 5 Pages |
Abstract
Activation of microglia has been implicated in various neurodegenerative disorders, and thus the inhibition of microglial activity may suppress these disorders. Earlier we designed and synthesized an NF-κB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ) that showed anti-inflammatory and anti-tumor activities in vivo. In the present research, we studied whether DHMEQ would inhibit the activation of mouse microglial cells. DHMEQ inhibited lipopolysaccharide (LPS)-induced activation of NF-κB in an electrophoresis mobility shift assay. It also inhibited LPS-induced secretions of TNF-α and IL-6 from mouse microglial cell line 6-1 cells.
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Authors
H. Takatsuna, S. Morita, T. Nagatsu, M. Sawada, K. Umezawa,