Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9004438 | Biomedicine & Pharmacotherapy | 2005 | 7 Pages |
Abstract
We report the synthesis of a novel alkyl polysulfated sialic acid derivative denoted as NMSO3. NMSO3 exhibited potent inhibition against both laboratory and clinical human immunodeficiency virus type 1 (HIV-1). The anti-viral activity of this compound (1Â uM) was compared to dextran sulfate (3Â uM), and was found to be more potent against HIV-1IIIb than AZT (10Â uM). The anti-coagulation time was more than 15-fold shorter than that of dextran sulfate. An in vivo anti-viral study of NMSO3 in NOD-SCID-PBL mice HIV model showed complete protection of the animals from virus challenge at the concentration of 10Â mg/kg. This suggests that NMSO3 can be effective in the treatment of HIV-infected individuals.
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Authors
Masaki Terada, Shuji Fujita, Isao Suda, Robert Mastico,