Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9004542 | Biomedicine & Pharmacotherapy | 2005 | 10 Pages |
Abstract
Mannich bases of gatifloxacin were synthesized by reacting them with formaldehyde and several isatin derivatives. Their chemical structures have been confirmed by means of their IR, 1H-NMR data and by elemental analysis. The compounds were tested in-vitro against a panel of 58Â human tumour cell lines derived from nine neoplastic diseases. Among them compound 1-cyclopropyl-6-fluoro-8-methoxy-1,4-dihydro-4-oxo-7[[N4-(3â²-sulphadoximino)-1â²-(5-bromoisatinyl) methyl]-3-methyl N1-piperazinyl]-3-quinoline carboxylic acid (6) emerged as a potent anticancer agent being more active than standard DNA topoisomerase II inhibitor, etoposide against 30 cancer cell lines.
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Authors
Perumal Yogeeswari, Dharmarajan Sriram, Ramkumar Kavya, Sonali Tiwari,