Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9004943 | Biomedicine & Pharmacotherapy | 2005 | 5 Pages |
Abstract
Anti-tumoral polyoxomolybdates have been investigated in the course of study of the medical application of polyoxometalates as discrete cluster anions of metal oxides. [NH3Pri]6[Mo7O24]·3H2O (PM-8) has been recognized as one of significantly anti-tumoral polyoxomolybdates. PM-8 inhibited the cell growth of human pancreatic cells (AsPC-1) depending on the dose. DNA ladder formation and DNA fragmentation were observed by Hoechst and TUNEL staining and flowcytometry analysis. The ratio of apoptotic cells were 29%, 35%, and 57% with treatment of PM-8 after 24, 48, and 72 h, respectively, which suggested that the anti-tumor activity of PM-8 results from the activation of the apoptotic pathway. Polyoxomolybdates provide promising, novel anti-tumor agent, especially for the treatment of cancers that are difficult to treat.
Keywords
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Authors
A. Ogata, S. Mitsui, H. Yanagie, H. Kasano, T. Hisa, T. Yamase, M. Eriguchi,