Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9008260 | International Immunopharmacology | 2005 | 10 Pages |
Abstract
Th1 stimulus for Th2-skewed immune response during infancy is important for reduction of incidence of allergic diseases. We examined effects of oral administration of bovine colostrum on local immunity in intestine in adult mice. C57BL/6 mice were orally given bovine colostrum or control milk for 1, 3 or 6 months and intestinal microflora, fecal IgA, and lymphocyte population of gut-associated lymphoid tissues and their abilities of cytokine production were examined. Although the cell populations of intestinal intraepithelial lymphocytes (i-IEL) were not remarkably changed, the T cells in i-IEL were polarized to Th1 type after oral administration of bovine colostrum. Intestinal microflora and IgA levels in feces were not changed by oral administration of bovine colostrum. These results suggest that colostrum stimulates directly to i-IEL to polarize Th1 type, which may protect from infectious diseases and allergic diseases mediated by Th2 type responses.
Keywords
Th2MLNT helperIL-12Th1TregIFN-γIL-10T helper 1Fas-LGALTT helper 2IL-4FITCTGF-β1C57BL/6MϕAllergyinterferon-γinterleukin-12interleukin-4Interleukin-10gut-associated lymphoid tissuesTransforming growth factor-β1CytokineFas-ligandphycoerythrinfluorescein isothiocyanateintestinal intraepithelial lymphocytesMacrophageRegulatory T Peyer's patchmesenteric lymph nodeColostrum
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Yasuko Yoshioka, Satsuki Kudo, Hitoshi Nishimura, Toshiki Yajima, Kenji Kishihara, Kimika Saito, Tatsuo Suzuki, Yumiko Suzuki, Shinsuke Kuroiwa, Yasunobu Yoshikai,