Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9012680 | Life Sciences | 2005 | 13 Pages |
Abstract
The effect of Bacillus Calmette-Guérin (BCG) treatment in allergic pulmonary reaction was studied in mice genetically selected accordingly to a High (H-IVA) or Low (L-IVA) antibody responsiveness. Mice were immunized with ovalbumin (OVA) or OVA plus BCG. Two days after nasal antigenic challenge, seric IgE and IgG1 anti-OVA, eosinophils in pulmonary tissue, inflammatory cells in bronchoalveolar lavage and the compliance and conductance of respiratory system were evaluated. H-IVA mice were found more susceptible than L-IVA, and BCG was able to inhibit simultaneously the production of IgE, the bronchopulmonary inflammation and bronchial hyperresponsiveness in these genetically selected mice.
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Authors
Myrthes Toledo Barros, Milena Marques Pagliarelli Acencio, Maria Lúcia Bueno Garcia, Maria Fernanda Macedo Soares, Olga M. Ibañez, Milton Arruda Martins, Orlando Garcia Ribeiro, Jorge Kalil, Adenir Perini,