Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9012756 | Life Sciences | 2005 | 10 Pages |
Abstract
Higher glucose concentration resulted in a greater insulin response in both capsaicin- and vehicle-treated rats. However, glucose-stimulated insulin secretion was attenuated in capsaicin-treated animals, even though glucose levels did not differ. Glucagon levels did not differ between both groups. These results show that capsaicin-sensitive nerves are involved in glucose-stimulated insulin secretion, but are not directly involved in the regulation of blood glucose levels. Moreover, they suggest that capsaicin-sensitive nerves could be involved in the regulation of insulin sensitivity. We hypothesize that sensory afferents could play a role in the aetiology of pathologies where glucohomeostatic mechanisms are disturbed, as is in type 2 diabetes mellitus.
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Authors
Esther H.E.M. van de Wall, Dorte X. Gram, Jan H. Strubbe, Anton J.W. Scheurink, Jaap M. Koolhaas,