Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9012822 | Life Sciences | 2005 | 11 Pages |
Abstract
A novel pyridine derivative, 3,5-bis-(1-methyl-pyrrolidin-2-yl)-pyridine, and a pair of diastereomers of 1,1â²-dimethyl-[2,3â²]bipyrrolidinyl were isolated from the root of Nicotiana tabacum plants and identified as novel alkaloids by GC-MS analysis. The structures of these new alkaloids were confirmed by total synthesis. The affinities of these novel alkaloids, and other structurally related compounds for α4β2*, α7* neuronal nicotinic acetylcholine receptors (nAChRs), and for nAChRs mediating nicotine-evoked dopamine release from rat striatum were also assessed. The results indicate that these compounds do not interact with α7* nAChRs, but inhibit [3H]nicotine binding to the α4β2* nAChR subtype. The results also demonstrate that these compounds act as antagonists at nAChRs mediating nicotine-evoked dopamine release from rat striatum.
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Authors
Xiaochen Wei, Sangeetha P. Sumithran, A. Gabriela Deaciuc, Harold R. Burton, Lowell P. Bush, Linda P. Dwoskin, Peter A. Crooks,