| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9012944 | Life Sciences | 2005 | 8 Pages |
Abstract
We conclude that combination administration of a H1 and a H3 histamine receptor antagonist produces greater inhibitory effect on cutaneous microvascular permeability produced by released mast cell-derived histamine than either a H1 or H3 antagonist administered separately. In addition, the antiallergy activity of combining a H1 antihistamine with a H3 antagonist activity might provide a novel approach for the treatment of allergic skin diseases such as urticaria.
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Authors
Robbie L. McLeod, Garfield G. Mingo, William Kreutner, John A. Hey,