Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9016422 | Progress in Neuro-Psychopharmacology and Biological Psychiatry | 2005 | 5 Pages |
Abstract
This study examined gray matter (GM) volume abnormalities in first-episode, antipsychotic-naïve Indian schizophrenia patients. Magnetic resonance images of 18 schizophrenia patients and 18 matched healthy comparison subjects were analyzed by optimized voxel-based morphometry. Schizophrenia patients had significantly smaller global GM and greater global CSF volumes and smaller regional GM volume in superior frontal, inferior frontal, cingulate, post-central, superior temporal and parahippocampal gyri, inferior parietal lobule, insula, caudate nuclei, thalamus and cerebellum. Findings suggest limbic, heteromodal cortical, striatal, thalamic and cerebellar abnormalities in schizophrenia.
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Authors
Peruvamba N. Jayakumar, Ganesan Venkatasubramanian, Bangalore N. Gangadhar, Nimmagadda Janakiramaiah, Matcheri S. Keshavan,