| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9016694 | Progress in Neuro-Psychopharmacology and Biological Psychiatry | 2005 | 10 Pages |
Abstract
Homocysteine is a sensitive marker of folate and vitamin B12 deficiency. Numerous studies have confirmed the association between folate deficiency and depression. It is not completely understood whether homocysteine is solely a marker for folate deficiency or if it may play a more direct role in the expression of mood disorders. This review describes the biochemical, neurochemical and clinical correlations of folate deficiency and hyperhomocysteinemia in relation to depression.
Keywords
N-methyl-d-aspartateS-adenosylhomocysteineMTHFRBHMTtetrahydrobiopterinBH4SAHHcyCBSHAM-DPNMTCOMT5HTNMDAMHPG3-methoxy-4-hydroxyphenylglycolMTHFSAMdhfrS-adenosylmethionineDepressionbetaine-homocysteine methyltransferaseCNSdihydrofolate reductaseSerotonincentral nervous systemPhenylethanolamine N-methyltransferaseFolateMethyltetrahydrofolateMethylationHamilton Depression ScalehomocysteineVitamin B6vitamin B12HVA
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Biological Psychiatry
Authors
Teodoro Bottiglieri,