Article ID Journal Published Year Pages File Type
9017772 Toxicology and Applied Pharmacology 2005 11 Pages PDF
Abstract
The need to evaluate the potential for new drugs to produce adverse effects on respiratory function in non-clinical safety assessment is based on the known effects of drugs from a variety of pharmacological/therapeutic classes on the respiratory system, the life-threatening consequences of respiratory dysfunction, and compliance with world-wide regulatory safety guidelines. The objective of this article is to provide a brief overview of the functional disorders of the respiratory system and to present the strategy and techniques considered to be most appropriate for detecting and characterizing drug-induced respiratory disorders in non-clinical safety studies.
Related Topics
Life Sciences Environmental Science Health, Toxicology and Mutagenesis
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