Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9017772 | Toxicology and Applied Pharmacology | 2005 | 11 Pages |
Abstract
The need to evaluate the potential for new drugs to produce adverse effects on respiratory function in non-clinical safety assessment is based on the known effects of drugs from a variety of pharmacological/therapeutic classes on the respiratory system, the life-threatening consequences of respiratory dysfunction, and compliance with world-wide regulatory safety guidelines. The objective of this article is to provide a brief overview of the functional disorders of the respiratory system and to present the strategy and techniques considered to be most appropriate for detecting and characterizing drug-induced respiratory disorders in non-clinical safety studies.
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Authors
Dennis J. Murphy,