Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9020853 | Vascular Pharmacology | 2005 | 6 Pages |
Abstract
We studied the role of oxidant species in contraction responses to angiotensin II in human conduit arteries. Treating radial artery segments with the anti-oxidants with a range of inhibitors, affecting the redox dependent pathways, markedly reduced contraction to angiotensin II. In parallel experiments, oxidative fluorescence was assessed and compared in human radial and internal mammary artery. Angiotensin II induced superoxide anion production may be mediated by multiple inter-dependent rate-limiting enzymes in both types of artery.
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Authors
Valentina O. Püntmann, Monira B. Hussain, Manuel Mayr, Qingbo Xu, Donald R.J. Singer,